Process of preparing 3-pyrazolidones



United States Patent PROCESS OF PREPARING 3-PYRAZOLIDONES George A. Reynolds and John F. Tinker, Rochester, N. Y., assignors to Eastman Kodak Company, Rochester, N. Y., a corporation of New Jersey No Drawing. Application August 3, 1953, Serial No. 372,167

' 12 Claims. (Cl; 260310) This invention relates to a process for the preparation.

of 3-pyrazolidone compounds having the general formula:

HN Hi wherein R represents either a mononuclear aryl group of the benzene series or a heterocyclic nucleus such as those of the benzothiazole series. The 3-pyrazolidone compounds of the invention are particularlyuseful as" developing agents for photographic silver halide emulsion layers.

The 3-pyrazolidone compounds of the invention having the above general formula are prepared by heating a hydroxy fatty acidhydrazide having the general formula: R-NH-NH-CO-(CH2) nOH wherein theR group is as above mentioned, and n is 2, g

3 or 4 in an inert' organic solvent having a boiling point of at least about 110 C., such as toluene or xylene,

and in the presence of an acid dehydration catalyst such as p-toluenesulfonic acid. Heating of the hydrazine under these conditions brings about cyclization of the hydrazide whereby the corresponding 3-pyrazolidone' is (1951), in a detailed study, have shown'that the reaction product of ,B-propiolactone and aromatic hydrazines, such as phenylhydrazine, is a mixture of hydroacrylamide and B-alanine compounds, and our own work has shown, as will be seen hereinafter, that hydroxy fatty acid hydrazides are readily prepared by the reaction of f2 andzy-fatty acid lactones with hydrazines.

The following '3-pyrazolidones are representative of those which can be preparedby the process of our invention:

1-phenyl-3-pyrazolidone 1-m-nitrophenyl-3-pyrazolidone 1-p-nitrophenyl-3-pyrazolidone 1-p-chlorophenyl-3 pyrazo1idone l-p-cyanophenyl-3-pyrazolidone I a 1-p-18-methanesulfonamidoethylphenyl-Ei-pyrazolidone 1-p-fl-hydroxyethylphenyl-3-pyrazolidone 1- (p-carboxymethylphenyl) -3-pyrazolidone 1-p-tolyl-3-pyrazolidone 1-o-tolyl-3-pyrazolidone 1-m-tolyl-3-pyrazolidone p 1-(Z-benzothiazolyl)-3-pyrazolidone 2,743,279 Patented Apr. 24, 1 956 "ice As mentioned, the 3-pyrazolidone compounds are prepared by cyclizing the corresponding hydroxy fatty acid hydrazides. The hydroxy fatty acid hydrazides can be prepared in good yields by reacting theappropriate hydrazine, such as phenyl hydrazines or heterocyclichydrazines with fi-propiolactone, 5- or y-valerolactone or 'y-butyro-- lactone as shown in the following examples. Representative hydrazines useful in preparing the hydroxy fatty acid hydrazides by this process are the following:

4-morpholinomethylphenylhydrazine p-fi-Methanesulfonamidophenylhydrazine Phenylhydrazine 0-, m-, p-Tolylhydrazine,

o-, m-, p-Nitrophenylhydrazines,

0-, m-, p-Chlorophenylhydrazines, p-Cyanophenylhydrazine,

0-, m-, p-Bromophenylhydrazines, p fi flydroxyethylphenylhydrazine, Z benzothiazolylhydrazine Representative fl-hydroxy fatty acid hydrazides usefulin making the 3-pyrazolidones are therefore:

N-fl-hydroxypropio N-p 8-hydroxyethylphenylhydrazide 1 N-fi-hydroxypropio-N'-phenylhydrazide N-fi-hydroxypropio-Nf-p-cyanophenylhydrazide N-[i-hydroXypropio-N'-p-nitrophenylhydrazide v 'N-B-hydroXypropio-N-p-chlorophenylhydrazide' N-[i-hydroxypropio-N- p -methylsulfonamidoethylphenylhydrazide N-fi-hydroxyvalero-N'-phenylhydrazide N-y-hydroxybutyro-N'-phenylhydrazide N- y-hydroxyvalero-N'-phenylhydrazide Other hydroxy fatty acid hydrazides which can housed in the process contain the N-substituents of the above hydrazines. 1 p

Our process is unique in that it has been observed that if the above hydroxy fatty acid hydrazide compounds are heated in inert organic solvent media in the absence of an acid dehydration catalyst, no 3-pyrazolidone is obtained. Also, it appears essential that the hydrozy fatty acid hydrazides be heated in the presence of a dehydration catalyst in inert solvent media which have a minimum boiling point of atleast about C., such as o-Xylene, toluene, -l,l,2-trichloroethane, l,2'-diethoxyethane and chlorobenzene. That is, when the hydroxy fatty acid hydrazides are heated in the'presence of the dehydration catalystin lower boiling solvents, such as benzene, n5

butanol, Z-ethbxyethanol, methyl isobutyl ketone, etc.,-

cyclization does not take place and no 3-pyrazolidone compound has been found in the reaction mixture. Moreover, vin our process, hydracrylyl hydrazide, ob-

tained by reaction of hydrazine in B-propiolactone, does not cyclize to form the expected compound 3-pyrazolidone. Furthermore, we have found that the process apparently does not yield the expected 3-pyrazolidone if employed with hydroxy fatty acid hydrazides having the above general formula in which R is either a hydroxymethylphenyl, o-hydroxyethylphenyl, methoxyphenyl, acetamidophenyl, acetoxyphenyl, hydroxyphenyl or aminophenyl group. 7 Presumably, the nuclei representing R must therefore contain only inert substituents and must' be free of those substituents indicated.

New 3-pyrazolidones prepared as described hereinafter have the above general formula wherein the R group in the ,1-position of the 3-pyrazolidone nucleus represents.

either p-fi-hydroxylethylphenyl, Z-benzothiazolyl, p-,6-

3 math, u q am d pheny p-sya p or the -py ql qqes seeyl e h t =CCH7 N GO Hr OTCH h d t o catalysts su able for us i ou p es qlu h s ial usero i str n n r a is acids such as hydrochloric acid, sulfuric acid, p-toluenesu'l'fonic acid. nd m thah ulf ttis: arid.

The following examples illustrate the process of our invention:

EXAMPLE 1 The l-(hydroxyalkylphenyl)-3-pyrazolidones, the, by,- droxyalkyl group of which preferably contain from, 2 to 4 carbon atoms, are new compounds which; are particu: larly valuable inasmuch as the hydroxyalkyl group in-, creases the solubility of the comppupd'by of neutral solubilizing group. Thesec ompouiids retain. the valuable characteristics of the parent l-fphenyl-S-pyragolb done compound particularly as a silyerha li de develop rrgJ agent, whereas in other 3-pyrazolidone compounds 'cori a sles, fe e amp e nl p t ssyl or r atb p zee groups, the development activity is alteredsomewhat.

1- (p-fi-hydroxyethylphenyl) -3-pyrazolidone p'-fl-Hydroxyethylphenylhydrazine. was prepared by treatment of aqueous p-fl-hydroxyethylbenzenediazonium chloride with sodium bisulfite. The compound was isolated as the free base in 68% yield. A sample was recrystallized from benzene-ethanol, M. P; 127-129.

Analysis-Calcd. for CsHrzNzO: C, 63.2; H, 7.9; N,

' 18.6. Found: c, 63.6; H, 8.2; N, 18.6."

xylene had been added. The reaction mixture contained I the above desired pyrazolidone compound and some polymerized 1-(p-vinylphenyl)-3 pyrazolidone. To the cool mixture was added 100 cc. of ligroin, and the mixture was kept at 0-5 for 30 minutes. The solution was decanted, and the thin tafiy that remained extracted with portions of ethyl acetate. Thev solutions were. evaporated. to a small volume, cooled, and seeded; There. wasobtained 5.9 .54% yield, ofmaterial, M. P. 82.-,100:- was qq x ta l zat n o y as at y qlsls firl. af M95 F 6. with. athe Poor sw due. t ready solubility. A sample recrystallized. from alcohol: ethyl acetate and ethyl acetate-hexane having a melting point of 1 09-,-1 10 was analyzed.

.dnqlysl-Calcd. for ClIHMNBOZI C, 64.1; H, 6.8; N,

13:6. Fa a: c, 631,3,63; N,13.2,

EXAMPLE 2 1-phenyl-3-pyraz0lidone -fld i -N'r y r z s as par d. as follows:

To a solution of fl-propiolactone (14.4 g.; 0.2 mole) in 100 ml. of benzene was slowly added, with stirring, 21.6 g. (0.2 mole) of phenylhydrazine. A- white solid began to separate almost immediately, and the solution became warm. The reaction mixture was heatedtonthe. steam bath for, an hour with stirring. After cooling .to:

10, the white solid was collected and air dried (yield 28.5 g. or 80%). A sample on recrystallization from ethyl' acetate melted at 141l42 andanalyzed satisfactorily. The M. P. of the crude product was 138-l40.

In preparing the desired product l-phenyl-3-pyrazolidone, a 10-g. sample of the crude product from the reaction described above wandigsgolved in 75 mol. of hot ene T thi s l tti nu s a e -5 of p-t uenesulfonic acid, and the solution refiuxed,'using a Dean and Stark water separator, until no more water was col lected. On cooling, white crystals; of l-phenyl-l-pyrazolidone separated and were collected on a Buchuer funnel. More of the product was obtained when the filtrate was diluted with an, equal; volume of petroleum ether. The yield of product was 6 g. (66%), melting at 117. After one recrystallization from. ethyl acetate, the M. P. was raised to 120-121", and there was no depression in M. P. when the product was mixed with ample f .-p e y -3= ra ol .don pr paredby a i ferent procedure.

' E AMPLE To a solution of 11.2 g. of p-tolylhydrazine in 35 ml. of dry benzene was added -5.7 ml. of ,B-propiolactone. After, ,4 hours at room temperature, the mixture was cooled, filtered, and, the solid, recrystallized, from a mixture of ethyl acetate and ethanol. The yield. of N-ptolyl-N-,ii-hydroxypropiohydrazide, M. P. 132:136" (3., was 5.6 g- O1; 311%. A sample was recrystallized several times from ethyl acetate for analysis (M. P. 135-136 C.).

Anglysis.... Calcd. (CIQHMNZOZ, M. W. 194): C, 62.0; H, 7.2; N. 14.4. Found: C, 62.6; H, 7.3; N, 14.5.

qlutiqn o 19.8.. f N-r- Q ah oxypmpioydrezitlein 2. 2 7 of x len conta in gr-toluucrst li aip ac d sre wse r 21/1 our th n 8 m t'xy ena was distilled-om an th ixtu e c o e nd te ed, The-fi tra e as ur h v q a e q q sd, d ter d ,A wta of; 7- of c ud -prtol -3 -pyta q (75 k) .2. 6 w s a n crystallization from ethyl acetate (73% recovery) raised hs-me tit srni t9 C- EXAM E F tty stains Q p-li trpnhcn lhy azi e n mlo se s wast ea ed ith 9. mlf'fl-propip aswne he mixt ra asellpwcd o tand ve n h e evaporated ;?l. fyrfilte sdlfini he, olid er -ysta lize r m th e l Asmwielsi q 24s- 3%) of y llo o i 0*. 57 was htatn sh The amn e Pr a for aalys has; 44: 757- rzqlx i w fial diq -QHnN QaM- 2 8 0,;

-9; N 81 F und (3, 3,41 1 N, 18.

I -p-nitrophenyl-3 pymzolidone A mixture of 2 3. g. of, the recrystallized N-p-nitrophenyl-N-fl-hydroxypropiohydrazide, 2 g. of p-toluenea iqaie acid, and 0 m1.- 'Xyl ne w s fluxed under amen-Sta k ract r mimi Q nd hep seo hea removed. The mixture, cooled to 25, was filtered, and. the solid recrystallized from a mixture of ethyl acetate and ethanol. The first crop amounted to 5.3 g, (25%), M. P. 194-197". A sample for analysis, placed in the bath at 205 melted at 212-2 1.4.

Analysis.-Calcd for Csl lpNaQs, W. 207: C, 52.2; H, 4.3; N, 20.3 Found; C, 51.7; H, 4.5; N, 1 9,4.

EXAMPLE 5 N -p-cyanopheny l-N '-fl-h ydroxy propioh ydrazida A solution of 21.5 g. of p-cyar ophepylhydrazine. ih t it 400 ml. of hot benzene was treated-with; 11 ml propiolactone, and the mixture refluxed for 2 hours. The mixture was cooled to room temperature and filtered, the filtrate evaporated and cooled, yielding 9.7 g. (30%) of crude product, M. P. 154-158 C. A sample recrystallized for analysis from ethyl actate melted at 159-160 C.

Calcd (C10H11N302, M. W. 205): C, 58.5; H, 5.4; N, 20.5. Found: C, 58.2; H, 5.0; N, 20.8.

1 -p-cyanophenyl-3-pyrazoli done A mixture of 4.5 g. of N-p-cyanophenyl-N- 3-hydroxypropiohydrazide and 300 mil. of xylene was heated to boiling, and 10 ml. of 0.5 N p-toluenesulfonic acid in dry.

xylene was added. Themixture was refluxed under a water separator for 1 hour, cooled, and the xylene decanted. -The residue was recrystallized twice from a mixture of ethyl acetate and ethanol, yielding 0.6 g.

(1 5%) of product, M. P. 194-1952 of analytical purity. Analysis.-Calcd for CroHsNsO, M. W. 187: C, 64.2; H, 4.8; N, 22.4. Found: C, 63.5; H, 5.0; N, 22.2.

EXAMPLE 6 v N -'p-methtznesulfomrmidoethylphenyl-N '-,8-hydr0xyprapiohydrazide A solution of 17.5 g. of p-B-methanesulfonamidoethylphenylhydrazine in 250 ml. of warm dioxane was treated with 4.8 ml. of fl-propiolactone. After the solution had stood some time, 30 ml. of saturated aqueous potassium carbonate was added, and the mixture shaken intermittently for several hours. The upper phase was separated,

. and dried over solid potassium carbonate; a dark oil separated during the last steps; it was discarded. The dry solution was evaporated to dryness, and the resulting tafiy was recrystallized twice from a mixture of ethyl acetate and ethanoLyieIding 4.1 g. (18%) of solid, M. P. 113114. The crude yield is larger, but the purity is unsatisfactory.

Analysis.-Calcd for C12H19N304S, M. W. 301: C, 47.9; H, 6.3; N, 13.9; S, 10.6. Found: C, 48.1; H, 7.0; N, 14.2; S, 10.3.

1-p-;8-methanesulfonamidoethylphenyl-3-pyrazolidone A suspension of 4.1 g. of N-p-fl-methanesulfonamidoethylphenyl-N'43-hydroxypropiohydrazide in 350 ml. of

xylene and 0.5 g. of PrtOhlCI'lCSlllfQIliC acid was refluxed under a water separator for 90 minutes. The mixture was cooled to 20 C. and the xylene decanted. The residue was recrystallized from a mixture of ethyl acetate and ethanol, yielding 2.5 g. (65%) of crude product, M. P. 133.135 C. A sample for analysis was recrystallized from ethanol,'M. P. 142-144 C.

Analysis.-Ca1cd for C12H11N3O3S, 283: C, 50.9; H, 6.0; N, 14.8; S, 11.3. Found: C, 51.2; H, 5.8; N, 14.7; S, 11.3.

EXAMPLE 7 A mixture of 15g. of 2-hydrazinobenzothiazole, 100 ml. of benzene, 250ml. of dioxane, and 6 ml. of ,8- propiolactone was refluxed for 2 hours, then cooled to room temperature and filtered. There was obtained 3.1 g. of solid, M. P. 200-201, the infrared absorption of which shows a strong carbonyl absorption, which is missing in the spectrum of the starting material.

Analysis.Calcd for C10H11N3O2S: C, 50.7; H, 4.6; N, 17.7. Found: C, 51.3; H, 4.9; N, 17.9.

I-(Z-benzothiazolyl) -3-pyrazolid0ne A solution of 2.8 g. of the hydrazide in 200 ml. of 1,1,2-trichloroethane was heated to reflux, 2 ml. of methanesulfonic acid added, and the solution refluxed for two hours.

The solution was cooled, and crystals separated after some time. Fractional recrystallization from ethyl alcohol yielded 100 mg. of product, M. P. 215216 C.

6 Armlysis.--Calcd for C10H9N3OS (mol. wt. 219): C, 54.8; H, 4.1; S, 14.6. Found: C, 54.5; H, 4.5; S,'1'4.4.

EXAMPLE 8 N -B-hyd roxypropio-N 0-tolylhydrazide A dry benzene solutionof o-tolylhydrazine, prepared from 22 g. of the hydrochloride, was treated with 8.7 ml.

of ,Bpropiolactone and allowed to stand overnight. The slurry was filtered at 25 no more material could be isolated from themother liquors, yielding 18.4 g., 68%, of crude product. Recrystallization from'ethanol in'78% recovery yielded satisfactory material, M. P. 135-137? C. The analytical sample melted at 138-139 C.

Analysis-Calcd for CmHmNzOz (mol. wt. 194): C, 62.0; H, 7.2; N, 14.4. Found: C, 62.0; H, 7.5; N, 15.4,

I-(O-tolyl)-3-pyraz0lidone A solution of 10 g. of the above hydrazide in 100 ml. of hot 1,1,2-trichloroethane was treated with 2 ml. of

methanesulfonic acid, and the mixture refluxed for 3' hours. The solution was cooled well and filtered, yielding'2.6 g. (29%) of product, M. P. 195'-197 C. A little more was obtained from the mother liquors.

A sample, recrystallized from ethyl acetate, was analyzed.

Analysis.--Calcd: C, 68.2; H, 6.8; N, 15.9. Foundr- N, 16.2.

EXAMPLE 9 This compound was prepared in a fashion identical to the preparation of the above ortho isomer. From g. of the salt and 18 ml. of fl-propiolactone was obtained 20.6 g. (37%) of-crude hydrazide, recrystallized with 52% recovery, melting at 112-113 C., An analytical sample melted at 117-118 C.

Analysis.-Calcd for C10H14N202 (mol. Wt. 194): C,

62.0; H, 7.2; N, 14.4. Found: C, 61.9; H, 7.5; N, 14.8. I

This compound was prepared in the same manner as the above ortho isomer except. that no solid appeared when the trichloroethane solution was cooled. The solution was evaporated to dryness, and fractionally crystallized from ligroin-ethyl acetate. Finally, 300 .mg. of product of analytical purity was obtained, M. P. 178- 179 C.

pared. Benzal-p (4 morpholinomethyl) phenylhydrazone has M. P. 153-154 C., recrystallized from alcohol.

'N-fi-hydroxypropio-N'4-(4 morpholinomethybphenylhydrazide GHQ-CH2 HOOHQCHaCONH NH OOH2 N/ O CHrOHz Sixteen grams of N-p-hydrazinobenzylmorpholine was dissolved in benzene, the solution filtered, and 4.8 ml. of fl-propiolactone added. After several days, the benzene was evaporated and the residue crystallized from ethyl acetate. The first crop amounted to 5.4 g. 25% yield, M. P. 134 C. Another recrystallization gave a sample of M. P. l32134 C.

T hydrazid wa-hx rqxyp op mo aho me hy a-phe ylhydrazi e A g-l. a efluxe with 5 00 m1. of xylene and, 1 g fi p.-,toluenesulfopic acid for 3 hours. The cooled, mixture-was filtered from some unidentified polymerix material, and evaporated to dryness. The residue was crystallized from ethyl acetate, yielding -2 g-,.,5 y e d .Q produ 2. -12. Q)-

N, 14.1. Found: c. 67.2; H, 7.7; N, 14.4.

EXAMPLE 11 -l rhydmxyaalero-Nqvhenx hydmzide A dry 'benzene solution of-phenylhydrazine was treated with; 20.5 g. of fi-valerolactoue and allowed to stand overnight. The slurry was cooled and filtered, yielding 19.3 g. of crude product. Recrystallization from ethyl acetate in 81% recovery yielded satisfactory material, P. 117-1 18 C.

Analysis.Caled C, 63.5; H, 7.7; N, 13.5. Found: C. 63.8; H, 7.6; N, 13.3.

N-y-hydroxybutyro-N=pheny1hydrazide was prepared as describedin Ber. 6Q, 139 9.

AMPL 12 N-y-hydroxyvalem-N-phenylhydrazide A mixture of 100 cc. of phenylhydrazine and 100 cc. of fyz-YfllfiI'OlfiCtOflfi were heated at 90 C. overnight. The mixture-was allowed to cool and 95 g. of solid separated. This. was. recrystallized from a mixture of ethyl alcoholethyl acetate, yielding 44 g. (47%) of compound; afterfurther recrystallization, a compound of M. P. 82-83 C. was recovered.

Alzalysis..Calcdi C; 63.5; H; 7.7; N, 13.5. Found: C, 61.7; H; 8.0; N, 14.7.

What we claim is:

1. A method for preparing a 3-pyrazolidone which comprises heating a compound having the general formula wherein R represents a member of the class consisting of p-B-hydroxyethylphenyl; phenyl, o-tolyl, m-tolyl, p-tolyl, mand p-nitrophenyl, p-cyanophenyl, p-[s-methanesulfonamidpethylphenyl; p-chlorophenyl and p-(4- morpholinomethyD-phenyl groups, in an inert organic solvent having a hoiling point of at least about 110 C., in thepresence of an acid dehydration catalyst and at a temperature sufficient to form saidS-pyrazolidone.

2. A method for preparing 1-phenyl-3-pyra zolidone which comprises heating N-fi-hydroxypropiorN phenylhydrazide in an inert organic, solvent having a boiling point of at least about 110 C., in the presence of an acid dehydration catalyst and at a temperature sufficient to form, l-phenyl-iipyrazolidone.

3. A method "for preparing l=phenyl3-pyrazolidone which comprises heating N=fi hydroxypropio N phenylhydrazinein xylene at reflux temperature in the presence of p-toluenesulfonic acid until l-phenyl-3-pyraaolidone is obtained; I

4. A method for preparing 1'-(p-B-hydroxyethylpheny -py d0ne hich campus s he -fiy ypropio-N'-p-B-hydroxyethylphenylhydrazide in an inert organic solvent-having a boiling-point of at least 110 C.,

in the presence of an acid dehydration-catalyst and at a temperature sufficient to form said first-mentioned compound.

' 5. Amethod for preparing 1-(p-fi-hydroxyethylphenyl) 3-py-razoli'done which comprises heating N-fi-hydroxypropio-N-p-f3-hydroxyethylphenylhydrazide in xylene at reflux temperature in the presence of p-toluenesulfonic acid until said first-mentioned compound is obtained;

6. A method for preparing 1-(p-cyanophenyl)-3-pyhydrazide in an inert organic solvent having a boiling point of at least about I l-0 C., in the presence of an acid, dehydration catalyst and at a temperature sufficient to form said 3-pyrazolidone.

10. A method for preparing 1-p-tolyl-3-pyrazolidone which comprises. heating N-p-.tolyl-N'-p-hydroxypropiohydrazide in xylene at reflux temperature in the presence ofp-toluenesulfonic acid until 1-p-tolyl-3-pyrazolidone is obtained;

11. The process of claim 1 wherein the organic solvent is xylene and the catalyst is p-toluenesulfonic acid.

12. The process of claim 1 wherein the organic solvent is toluene and the catalyst is methanesulfonic acid.

References Cited inthe file of this patent UNITED STATES PATENTS 2,289,367 Kendall July 14, 1942 2,688,024 Kendall et al. Aug. 31, 1954 FOREIGN PATENTS 650,911 Great Britain Mar. 7, 1951 679,677 Great Britain Sept; 24, 1952 OTHER REFERENCES Spasov et al,: Chem. Abst., v01. 44, col. 1491 (1950). 

1. A METHOD FOR PREPARING A 3-PYRAZOLIDONE WHICH COMPRISES HEATING A COMPOUND HAVING THE GENERAL FORMULA 